• Combination Therapy

    Regenetek’s Combination Stem Cell and Vascular Therapy

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  • Regenerative Medicine

    ‎The Most Current Information Available from Leading Scientists and Clinical Trials World-wide

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  • Patient Registry Software

    Application of Technology to Make Any Size of Study Self-Managing and Affordable

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  • Neurodegenerative Disorders

    The Latest Updates on Diseases Treatable Through Regenerative Medicine

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  • Topical Commentary

    Opinions from Regenetek and Leading Authorities in Regenerative Medicine

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About: Doug Broeska

Doug Broeska is a PhD Medical Researcher and CEO of Regenetek Inc, a Canadian Biotech Research firm working with several hospitals and clinics world-wide to develop medical procedural protocols for neurodegenerative disease management.

Recent Posts by Doug Broeska

Introductory word

Hundreds of thousands of undocumented therapies occur in clinics world-wide each year under the label of ‘medical tourism’. Even if physicians in these clinics wanted to follow their patients, there has been no method of doing so. Until now. Regenetek Research recognizes that there is a high need for a method and a study design that provides proof of both safety and efficacy for new treatment interventions such as autologous stem cell therapies or unsanctioned vascular surgeries. These types of medical interventions present viable choices for patients beyond conventional drug therapies that only treat symptoms. My goal in writing these articles is to point out the gaps in the research while we look for the truth, not reinforce the biases in the science.

Proof that STAP Cells Can Kill

Stimulus-triggered acquisition of pluripotency or STAP was supposed to be the new medical breakthrough based on the science of stimulating any old human cells to become pluripotent stem cells by treating them with certain growth factors, acidic baths, or other manipulation. This technological leap forward would mean that ordinary blood cells for instance, could be treated to become neurons in the brain, etc, and such a discovery could lead to cures for Alzheimer’s and MS among many other diseases. STAP would have been a much easier way to produce stem cells than current methods as neither nuclear transfer nor transcription factors would have been necessary in their growth. But the ‘science of STAP’ is turning out to be the present day equivalency of alchemy, the notion that lead can be turned into gold.

Subject David Echt’s Case in Retrospect

To provide some background here for David Echt’s post, 6 months after treatment in March of 2014, David wasn’t experiencing the recovery we are seeing in other patient/subjects over the same time period, post-therapy. Although there were some important improvements, there was no functional difference in his affected right leg whatsoever; it was still as paralyzed as it had been for the past 6 years. This didn’t make a lot of sense to us. We knew he was on Metformin for his diabetes, but as far as we knew, that shouldn’t have interfered with the activity of the stem cells…OR SO WE THOUGHT. Then we came across a new article entitled ‘The paradoxical effect of metformin on endothelial cells and angiogenesis’. The research concluded that the drug Metformin would have precisely the OPPOSITE effect of what would be expected. Instead of fostering stem cell activity and endothelial growth, it INHIBITED these growth activities, which was a stunning surprise to the researchers. Metformin would therefore inhibit the formation of capillary networks, negate the trophic effect of stem cells in the brain, and likely disrupt endothelial, myelin and neuronal growth. So despite what we THOUGHT WE KNEW, many drug interactions with stem cells are difficult to make recommendations about these drugs because there has not been enough work done in this area of study. It really requires a deep dive into medical journals. What we are witnessing with David’s dramatic demonstration is real medical pioneering stuff. And now we know a couple more things. Because David’s recovery has now resumed, we have a good demonstration of the lasting effect of the ‘type’ of stem cells (mesenchymal neural progenitor cells or ‘true stem cells’) we’re typing, isolating, and colonizing for reinfusion.

Chemotherapy with Stem Cells, HSCT for MS is Wrong AND Dangerous

Notice To readers:

As a result of a backlash by supporters of Hematopoietic stem cell transplantation for multiple sclerosis, I have modified this post and intend to produce the evidence that supports my opinion-based assertions through clinical study evidence and links within the finished article.

Risk Factors and Potential Causes of MS*** The UNUSUAL Suspects

Someone asked me the other day what exactly causes the neurotoxic leakage of fibrinogen across the blood brain barrier in the MS central nervous system leading to lesions in the brain and subsequent neurologic symptoms. They meant, WHY are these vessels in the MS brain so prone to injury? If you’ve been reading my blogs here, you know that I’ve been heavily promoting that this leakage of fluids sets off the cascade of events that incites an immune response in the brain (CNS) and subsequent inflammation. This is where the research is taking us (although neurologists do not generally know of this research because it’s in the area of vascular medicine). We can also turn that question around to ask why that same type of injury and subsequent leakage doesn’t occur in the vast majority of the population. The Davalos UCSF study (among other studies) has shown that this leakage is most certainly ‘the cause’ of MS in those patients who are predisposed to disease development. We have seen thinner walled veins and strange valvular anomalies in most if not all MS patients. Zamboni based his hypothesis around weakened jugular veins but didn’t carry his observations, nor his treatment far enough. He had to look further upstream to find the real problem. So what is really going on here that is causing these venous lesions in the MS brain?